Selected Publications on Mitochondria and Aging

Cormio A, Milella F, Vecchiet J, Felzani G, Gadaleta MN, Cantatore P. Mitochondrial DNA mutations in RRF of healthy subjects of different age. Neurobiol Aging 2005 May;26(5):655-64. PMID 15708440
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, Larsson NG. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004 May 27;429(6990):417-23. PMID 15164064
Khan SM, Bennett JP Jr. Development of mitochondrial gene replacement therapy. J Bioenerg Biomembr 2004 Aug;36(4):387-93. PMID 15377877
Drew B, Leeuwenburgh C. Ageing and subcellular distribution of mitochondria: role of mitochondrial DNA deletions and energy production. Acta Physiol Scand 2004 Dec;182(4):333-41. PMID 15569094
Chomyn A, Attardi G. MtDNA mutations in aging and apoptosis. Biochem Biophys Res Commun 2003 May 9;304(3):519-29. PMID 12729587
Pesce V, Cormio A, Fracasso F, Vecchiet J, Felzani G, Lezza AM, Cantatore P, Gadaleta MN. Age-related mitochondrial genotypic and phenotypic alterations in human skeletal muscle. Free Radic Biol Med 2001 Jun 1;30(11):1223-33. PMID 11368920
Tanaka M, Gong J, Zhang J, Yamada Y, Borgeld HJ, Yagi K. Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis. Mech Ageing Dev 2000 Jul 31;116(2-3):65-76. PMID 10996007
de Grey AD. Mitochondrial gene therapy: an arena for the biomedical use of inteins. Trends Biotechnol 2000 Sep;18(9):394-9. PMID 10942964
Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 1999 Oct 22;286(5440):774-9. PMID 10531063
Ozawa T. Genetic and functional changes in mitochondria associated with aging. Physiol Rev 1997 Apr;77(2):425-64. PMID 9114820
Ozawa T. Mitochondrial DNA mutations associated with aging and degenerative diseases. Exp Gerontol 1995 May-Aug;30(3-4):269-90. PMID 7556507
Ozawa T. Mechanism of somatic mitochondrial DNA mutations associated with age and diseases. Biochim Biophys Acta 1995 May 24;1271(1):177-89. PMID 7599206
Kadenbach B, Munscher C, Frank V, Muller-Hocker J, Napiwotzki J. Human aging is associated with stochastic somatic mutations of mitochondrial DNA. Mutat Res 1995 Oct;338(1-6):161-72. PMID 7565871
Hayakawa M, Sugiyama S, Hattori K, Takasawa M, Ozawa T. Age-associated damage in mitochondrial DNA in human hearts. Mol Cell Biochem 1993 Feb 17;119(1-2):95-103. PMID 8455592
Muller-Hocker J, Schneiderbanger K, Stefani FH, Kadenbach B. Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing—a cytochemical-immunohistochemical study. Mutat Res 1992 Sep;275(3-6):115-24. PMID 1383754
Hayakawa M, Hattori K, Sugiyama S, Ozawa T. Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts. Biochem Biophys Res Commun 1992 Dec 15;189(2):979-85. PMID 1472070
Katayama M, Tanaka M, Yamamoto H, Ohbayashi T, Nimura Y, Ozawa T. Deleted mitochondrial DNA in the skeletal muscle of aged individuals. Biochem Int 1991 Sep;25(1):47-56. PMID 1772448
Linnane AW, Marzuki S, Ozawa T, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989 Mar 25;1(8639):642-5. PMID 2564461